Table 1.
Top 5 antigens selected in each VSA family.
| Unadjusted PPE† | Age and Bed-net use adjusted PPE | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Product ID | Gene ID | Subtype | Number of TM domains | Signal peptide | Protein length | Expressed region(aa) | Seroprevalence (%) | PPE (%) | 25% CI | 95% CI | P-value* | PPE (%)† | 25% CI | 95% CI | P-value |
| RIFIN | |||||||||||||||
| RS23 | PF3D7_0201000 | B-type | 1 | Yes | 312 | 21–113 | 27.27 | 81 | 17 | 95 | 0.0265 | (178.72) | (1,404.28) | 48.36 | 0.233 |
| RS189 | PF3D7_1254500 | B-type | 1 | Yes | 306 | 21–269 | 66.67 | 60 | 06 | 83 | 0.0366 | (172.68) | (1,427.32) | 51.32 | 0.254 |
| RS158 | PF3D7_1040600 | B-type | 1 | Yes | 326 | 28–283 | 75.76 | 59 | 3 | 82 | 0.0422 | (178.19) | (1,454.72) | 50.22 | 0.244 |
| RS163 | PF3D7_1041100 | B1-type | 1 | Yes | 334 | 24–291 | 74.24 | 59 | 3 | 82 | 0.0422 | (186.15) | (1,487.80) | 48.43 | 0.229 |
| RS89 | PF3D7_0700200 | A-type | 1 | Yes | 323 | 23–280 | 27.27 | 68 | −8 | 90 | 0.0657 | (240.24) | (1,789.11) | 38.72 | 0.161 |
| STEVOR | |||||||||||||||
| RS99 | PF3D7_0732000 | STEVOR | 1 | Yes | 296 | 198–256 | 83.33 | 58 | 2 | 82 | 0.0447 | (209.51) | (1,581.40) | 43.03 | 0.191 |
| RS186 | PF3D7_1254300 | STEVOR | 1 | Yes | 302 | 23–177 | 16.67 | 82 | −37 | 98 | 0.0979 | (198.98) | (1,519.75) | 44.81 | 0.204 |
| RS233 | PF3D7_1479900 | STEVOR | 1 | Yes | 304 | 202–264 | 43.94 | 52 | −15 | 80 | 0.0982 | (211.76) | (1,593.56) | 42.61 | 0.188 |
| RS92 | PF3D7_0700400 | STEVOR | 1 | Yes | 300 | 24–174 | 18.18 | 66 | −47 | 92 | 0.1496 | (208.04) | (1,568.66) | 43.14 | 0.192 |
| RS13 | PF3D7_0115400 | STEVOR | 1 | Yes | 301 | 23–178 | 31.82 | 49 | −37 | 81 | 0.1815 | (220.36) | (1,662.68) | 41.78 | 0.181 |
| SURFIN | |||||||||||||||
| RS264 | PF3D7_0113600 | SURFIN 1.2 # | 0 | No | 1893 | 636–1270 | 100.00 | 59 | 5 | 83 | 0.0378 | (257.84) | (1,913.01) | 36.39 | 0.148 |
| RS242 | PF3D7_1477600 | SURFIN 14.1 | 1 | No | 1953 | 905–1442 | 74.24 | 47 | −21 | 77 | 0.1294 | (196.91) | (1,559.65) | 46.88 | 0.215 |
| RS253 | PF3D7_0424400 | SURFIN 4.2 | 1 | No | 2380 | 1195–1796 | 60.61 | 45 | −25 | 76 | 0.1512 | (197.13) | (1,557.40) | 46.73 | 0.214 |
| RS256 | PF3D7_0402200 | SURFIN 4.1# | 0 | No | 2219 | 1605–2219 | 65.15 | 45 | −26 | 76 | 0.1560 | (205.19) | (1,625.60) | 46.02 | 0.207 |
| RS238 | PF3D7_1301800 | SURFIN 13.1# | 1 | No | 2164 | 658–1319 | 50.00 | −66 | −2.75 | 26 | 0.2191 | (259.91) | (1,870.19) | 34.25 | 0.140 |
TM domains, transmembrane domains. aaAmino acids. PPE, potential protective efficacy derived from the cox analysis hazard ratios. *In bold indicates statistically significant unadjusted PPE. No PPE remained statistically significant after adjustments for confounders (age and bed-net use). #Genes annotated as pseudogenes in PlasmoDB release 41.