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. 2020 May 12;10:554. doi: 10.3389/fonc.2020.00554

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Copyright © 2020 Lavin and Tiwari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In tune with EMT intracellular signaling. Extracellular stimuli bind to their receptors (shown here as a generic ligand binding a generic transmembrane receptor) and signal via canonical and non-canonical intracellular signaling pathways. Solid and dashed green ovals represent established and novel signaling pathways, respectively. Two-headed black arrows indicate inter-pathway interaction and regulation. Question marks represent unknown pathways involved. The yellow arrow indicates that the role of alternative splicing (sky blue spiked shape) remains to be investigated.