Table 3.
Secretory factors of HSCs contributing to BM microenvironment and bone homeostasis.
| Secretory factors | Function | Obesity | Life-style interventions |
|---|---|---|---|
| IL-1β | HSC activation (128) | ↓ (60) | ↓ Dietary restriction- reduced intake of amino acids (129) |
| MCP1 | HSC activation (128) | ↓ (60) | – |
| TNFα | HSC activation (128, 130) | = (60) | – |
| Wnt10b | Bone formation (131) | ↓ (132) | – |
| CXCL16 | Osteoblast migration (133) | – | – |
| TRAP | Osteoclast activation (134) | = (60) ↑(135) | ↓ Caloric restriction (136) |
| LIF | Osteoblast migration (133) | – | – |
| CTSK | Collagen degradation (137) | – | – |
| CTHRC1 | Bone formation (138) | – | – |
| Del-1 | HSC proliferation and differentiation (139) | – | – |
| TN-C | Bone remodeling and bone renewal (140) | ↑ (141) | – |