Table 3.
Clinicopathologic factors depending on the distance from the proximal resection margin in patients who underwent curative total gastrectomy, n (%)
| Variables |
PRM (cm) |
P value | |||
| ≤ 1.0 (n = 90) | 1.1-3.0 (n = 209) | 3.1-5.0 (n = 146) | > 5.0 (n = 214) | ||
| Age (yr)1 at operation | 57.1 ± 1.2 | 55.0 ± 0.9 | 54.6 ± 0.9 | 56.3 ± 0.9 | 0.330 |
| Sex | 0.364 | ||||
| Male | 64 (71.1) | 135 (64.6) | 92 (63.0) | 150 (70.1) | |
| Female | 26 (38.9) | 74 (35.4) | 54 (37.0) | 64 (29.9) | |
| Tumor location | < 0.001 | ||||
| Upper 1/3 | 81 (90.0) | 127 (60.8) | 32 (21.9) | 26 (12.1) | |
| Middle 1/3 | 8 (8.9) | 75 (35.9) | 103 (70.5) | 134 (62.6) | |
| Lower 1/3 | 1 (1.1) | 7 (3.3) | 11 (7.5) | 54 (25.2) | |
| Borrmann type IV | 17 (18.9) | 37 (17.7) | 14 (9.6) | 12 (5.6) | < 0.001 |
| Tumor size (cm)1 | 8.1 ± 0.5 | 7.6 ± 0.3 | 7.0 ± 0.3 | 5.9 ± 0.2 | < 0.001 |
| T stage | 0.873 | ||||
| T2 | 14 (15.6) | 30 (14.4) | 24 (16.4) | 42 (19.6) | |
| T3 | 44 (48.9) | 100 (47.8) | 67 (45.9) | 99 (46.3) | |
| T4 | 32 (35.6) | 79 (37.8) | 55 (37.7) | 73 (34.1) | |
| CLN1 | 30.7 ± 1.1 | 33.1 ± 1.0 | 32.2 ± 1.0 | 31.0 ± 0.7 | 0.216 |
| N stage | 0.495 | ||||
| N0 | 23 (25.6) | 74 (35.4) | 47 (32.2) | 59 (27.6) | |
| N1 | 14 (15.6) | 35 (16.7) | 21 (14.4) | 40 (18.7) | |
| N2 | 15 (16.7) | 41 (19.6) | 30 (20.5) | 42 (19.6) | |
| N3 | 38 (42.2) | 59 (28.2) | 48 (32.9) | 73 (34.1) | |
| AJCC stage | 0.587 | ||||
| Stage I | 8 (8.9) | 19 (9.1) | 14 (9.6) | 25 (11.7) | |
| Stage II | 29 (32.2) | 85 (40.7) | 53 (35.3) | 68 (31.8) | |
| Stage III | 53 (58.9) | 105 (50.2) | 79 (54.1) | 121 (56.5) | |
| Differentiation | 0.082 | ||||
| Differentiated | 29 (32.2) | 55 (26.3) | 34 (23.3) | 74 (34.6) | |
| Undifferentiated | 61 (67.8) | 154 (73.7) | 112 (76.7) | 140 (65.4) | |
| LVi | 57 (63.3) | 108 (51.7) | 75 (51.4) | 120 (56.1) | 0.231 |
| PNi | 54 (60.0) | 101 (48.3) | 92 (63.0) | 97 (45.3) | 0.002 |
| Recurrence | 44 (48.9) | 80 (38.3) | 48 (32.9) | 79 (36.9) | 0.648 |
| Local recurrence | 8 (8.9) | 10 (4.6) | 11 (6.9) | 14 (6.2) | 0.637 |
1
mean ± standard error. PRM: Proximal resection margin; RYGJ: Roux-en-Y gastrojejunostomy; CLN: Total number of collected lymph nodes; AJCC: American Joint Committee on Cancer; LVi: Lymphovascular invasion; PNi: Perineural invasion.