Table 7.

Analysis of the risk factors associated with recurrence-free survival in patients who underwent total gastrectomy using the Cox proportional hazard model

	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
Age	1.01 (1.00-1.02)	0.071	1.01 (1.00-1.02)	0.032
Female sex	1.23 (0.95-1.56)	0.118
BMI	0.96 (0.92-1.00)	0.067
Tumor location
Upper 1/3	Ref.
Mid 1/3	0.67 (0.51-0.87)	0.002
Lower 1/3	0.86 (0.57-1.30)	0.859
Tumor size	1.11 (1.08-1.14)	< 0.001	1.03 (1.00-1.07)	0.075
Borrmann type IV	2.84 (2.10-3.83)	< 0.001	1.91 (1.32-2.76)	0.001
CLN	1.00 (0.99-1.01)	0.612
T stage
T2	Ref.		Ref.
T3	2.20 (1.36-3.54)	0.001	1.31 (0.90-2.16)	0.289
T4	4.18 (2.60-6.72)	< 0.001	1.90 (1.14-3.18)	0.014
N stage
N0	Ref.		Ref.
N1	1.43 (0.89-2.31)	0.139	1.27 (0.77-2.07)	0.348
N2	2.35 (1.55-3.56)	< 0.001	1.68 (1.06-2.65)	0.026
N3	4.90 (3.43-6.99)	< 0.001	2.84 (1.87-4.32)	< 0.001
Diffuse type histology	1.14 (0.86-1.50)	0.357
LVi	2.41 (1.84-3.15)	< 0.001	1.44 (1.08-1.91)	0.013
PNi	1.71 (1.33-2.21)	< 0.001
PRM (cm)
0-1.0	Ref.
1.1-3.0	0.80 (0.55-1.15)	0.225
3.1-5.0	0.63 (0.42-0.95)	0.028
> 5.0	0.74 (0.51-1.07)	0.104

PRM: Proximal resection margin; RYGJ: Roux-en-Y gastrojejunostomy; CLN: total number of collected lymph nodes; LVi: Lymphovascular invasion; PNi: Perineural invasion.