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. 2020 May 18;6:15. doi: 10.1038/s41540-020-0132-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Demonstration of change in plasticity on altering the total number of positive feedback loops in GRHL2 network. Frequency of multi-stable parameters (PS2) increases as compared to WT upon the addition of positive feedback loop (GRHL2-miR200-ZEB-GRHL2) to the network (WT + 1) and reduces upon reduction of positive feedback loops by changing the GRHL2-ZEB-GRHL2 cycle to negative feedback (WT − 1). b Boxplots of PS2 vs. number of positive feedback loops for all the perturbed networks for GRHL2 and NRF2 networks. c Demonstration of network randomization (the in-degree and out-degree of each node is preserved; however, the number of inhibitory/excitatory nodes arriving at or emerging from a node are not necessarily conserved). d Same as B, but for randomized network topologies. p-value range for one-way ANOVA test are mentioned on the plots.