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. 2020 May 18;11(5):378. doi: 10.1038/s41419-020-2589-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Graphical representation of genes perturbed in the glycolysis pathway (upregulation in green and downregulation in red). b Hierarchical clustering heatmap analysis of metabolic genes in D7 cells treated with DMSO or WEHI-539. Colors in the heat map depict gene expression in units of SD from the mean across all samples (upregulation in red and downregulation in blue). c Expression of metabolic gene transcripts upon treatment with WEHI-539 on D7 cells. Error bars indicate standard deviation of three biological replicates undergoing independent differentiations. Asterisk (*) indicates P < 0.05 compared to DMSO control. A representative of at least two independent experiments is shown. d Glycolysis stress test and e individual component graphs of glycolysis, glycolytic capacity, glycolytic reserve, and non-glycolytic acidification in D7 cells treated with DMSO or WEHI-539. f Mitochondrial respiration and g individual component graphs of basal mitochondrial respiration, ATP production, maximal respiration, and spare respiratory capacity in D7 cells treated with DMSO or WEHI-539. Error bars indicate standard deviation of eight replicates. Asterisk (*) indicates P < 0.05 compared to DMSO control. A representative of at least two independent experiments is shown. “See also Figs. S3 and S4”.