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α-SYN regulated the transcription activity of Nurr1. (A) The schematic diagram of different Nurr1 promoter fragment luciferase plasmids. Dual-Glo luciferase assay determined the transcription activities of Nurr1 different promoter regions (−1,807/+199, −853/+199, −781/−594, −605/−418, −419/−233, and −233/−97 bp) in control cells (vector), α-SYNWT (WT) and α-SYNA53T (A53T) transfected cells (B–G). Data were expressed as mean ± SEM. **p < 0.01 vs. control cells, n = 3.
