Table 1.
Selected schizophrenia genes derived from genome-wide association study (GWAS) matching well-recognized ischemia-hypoxia response (IHR) genes of the brain.
| Gene symbol | Official full name | Main biological function |
|---|---|---|
| AKT3 | AKT serine/threonine kinase 3 | Serine/threonine protein kinase, growth factor signaling |
| ATP2A2 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Intracellular calcium pump associated with ER |
| BNIP3L | BCL2 interacting protein 3 like | Pro-apoptotic factor within the Bcl-2 family |
| CACNA1C | Calcium voltage-gated channel subunit alpha1 C | Alpha-1 subunit of a voltage-dependent calcium channel |
| CACNB2 | Calcium voltage-gated channel auxiliary subunit beta 2 | Subunit of a voltage-dependent calcium channel protein |
| CLU | Clusterin | Secreted chaperone |
| FGFR1 | Fibroblast growth factor receptor 1 | Growth factor signaling |
| FURIN | Furin, paired basic amino acid cleaving enzyme | Subtilisin-like proprotein convertase |
| HSPA9 | Heat shock protein family A (Hsp70) member 9 | Heat shock protein 70 gene family, primarily mitochondrial |
| HSPD1 | Heat shock protein family D (Hsp60) member 1 | Member of the chaperonin family, mitochondrial, HSP60 |
| HSPE1 | Heat shock protein family E (Hsp10) member 1 | Major heat shock protein, HSP10 |
| INA | Internexin neuronal intermediate filament protein alpha | Intermediate filament protein, in axonal cytoskeleton |
| MDK | Midkine | Secreted growth factor |
| MEF2C | Myocyte enhancer factor 2C | Transcription enhancer, trans-activating, DNA binding activities |
| NCAN | Neurocan | Modulation of cell adhesion and migration |
| NGEF | Neuronal guanine nucleotide exchange factor | Guanyl-nucleotide exchange factor activity |
| NRGN | Neurogranin | Postsynaptic protein kinase, binding calmodulin |
| OPCML | Opioid binding protein/cell adhesion molecule like | Cell adhesion, accessory role in opioid receptor function |
| PTK2B | Protein tyrosine kinase 2 beta | Protein tyrosine kinase, regulation of ion channels |
| RANGAP1 | Ran GTPase activating protein 1 | Regulation of nuclear transport, GTP-binding and exchange |
| RELA | RELA proto-oncogene, NF-kB subunit | NF-kappa-B transcription factor complex |
| SERPING1 | Serpin family G member 1 | Regulation of the complement cascade |
| SF3B1 | Splicing factor 3b subunit 1 | Splicing factor, component of U2 snRNP |
| SREBF1 | Sterol regulatory element binding transcription factor 1 | Transcription factor for sterol regulatory element-1 (SRE1) |
| SRPK2 | SRSF protein kinase 2 | Splicing factor, protein serine/threonine kinase activity |