Table 2.
Annotation of schizophrenia genes derived from genome-wide association study (GWAS) for a role of hypoxia-inducible factors (HIFs).
| Gene symbol | Official full name | Main biological function |
|---|---|---|
| ALDOA | Aldolase, fructose-bisphosphate A | Glycolytic enzyme |
| ALPK3 | Alpha kinase 3 | Protein serine/threonine kinase |
| BNIP3L | BCL2 interacting protein 3 like | Pro-apoptotic factor within the Bcl-2 family |
| BTG1 | BTG anti-proliferation factor 1 | Regulator of cell growth and differentiation |
| CDK2AP1 | Cyclin dependent kinase 2 associated protein 1 | Role in cell-cycle and epigenetic regulation |
| CPEB1 | Cytoplasmic polyadenylation element binding protein 1 | Regulation of mRNA translation |
| CPT1C | Carnitine palmitoyltransferase 1C | Regulation of beta-oxidation |
| CREB3L1 | cAMP responsive element binding protein 3 like 1 | Transfactor activated by ER stress |
| CUL3 | Cullin 3 | Role in polyubiquitination |
| EP300 | E1A binding protein p300 | Histone acetyltransferase, regulation of transcription |
| ESRP2 | Epithelial splicing regulatory protein 2 | Splicing regulator |
| FGFR1 | Fibroblast growth factor receptor 1 | Growth factor signaling |
| FURIN | Furin, paired basic amino acid cleaving enzyme | Subtilisin-like proprotein convertase |
| GPR135 | G protein-coupled receptor 135 | Orphan receptor |
| HSPA9 | Heat shock protein family A (Hsp70) member 9 | Heat shock protein 70 gene family, mitochondrial |
| KAT5 | Lysine acetyltransferase 5 | Histone acetyl transferases, DNA repair |
| KDM4A | Lysine demethylase 4A | Trimethylation-specific demethylase, repressor |
| KMT5A | Lysine methyltransferase 5A | Protein-lysine N-methyltransferase, SETD8 |
| LRP1 | LDL receptor related protein 1 | Low-density lipoprotein receptor |
| LSM1 | LSM1 homolog, mRNA degradation associated | Pre-mRNA splicing, mediating U4/U6 snRNP formation |
| MAD1L1 | Mitotic arrest deficient 1 like 1 | Role in mitotic spindle-assembly checkpoint, cell cycle |
| NEK1 | NIMA related kinase 1 | Serine/threonine kinase, cell cycle |
| NMB | Neuromedin B | Bombesin-like family of neuropeptides |
| OGFOD2 | 2-oxoglutarate and iron dependent oxygenase domain containing 2 | Oxidation-reduction process |
| OTUD7B | OTU deubiquitinase 7B | Deubiquitinase |
| PGM3 | Phosphoglucomutase 3 | Glycogen formation and utilization |
| PPP2R2A | Protein phosphatase 2 regulatory subunit Balpha | Negative control of cell growth and division |
| PRMT1 | Protein arginine methyltransferase 1 | Protein arginine N-methyltransferase |
| RALGAPA2 | Ral GTPase activating protein catalytic alpha subunit 2 | GTPase activator |
| RPTOR | Regulatory associated protein of MTOR complex 1 | Interaction with mTOR kinase, negative regulator |
| SF3B1 | Splicing factor 3b subunit 1 | Splicing factor, component of U2 snRNP |
| TCF4 | Transcription factor 4 | Helix-loop-helix transcription factor |
| ZEB2 | Zinc finger E-box binding homeobox 2 | DNA-binding transcriptional repressor |