Table 1.
DGKA function according to cellular localization.
| Cellular Compartment | Function | Species | Cell line (cell type) | References |
|---|---|---|---|---|
| Nucleus | Cell cycle regulation | Human | K562 (myelogenous leukemia) | (101) |
| Proliferation | Human | YT (natural killer cell) | (102) | |
| Mouse | CTLL-2 (T lymphocytes) | (102) | ||
| Lymphocyte activation | Rat | Primary thymocytes | (103) | |
| nra | Human | Jurkat (T cell leukemia) | (104) | |
| Mouse | NIH/3T3 (embryonic fibroblasts) | (105) | ||
| Cytosol | T cell activation | Human | Jurkat (T cell leukemia) | (104–107) |
| Rat | Primary thymocytes | (103) | ||
| Lipid metabolism, signaling | Swine | Primary vascular smooth muscle cells | (68, 106, 107) | |
| Human | Jurkat (T cell leukemia) | (68, 108) | ||
| Rat | L6 (skeletal myoblasts) | (71, 108) | ||
| nra | Mouse | NIH/3T3 (embryonic fibroblasts) | (105) | |
| Rat | Primary thymocytes | (103) | ||
| Membrane | T cell activation | Human | Jurkat (T cell leukemia) | (104, 106–110) |
| Mouse | Primary T cells | (111) | ||
| Lipid metabolism, signaling | Swine | Primary vascular smooth muscle cells | (68) | |
| Mouse | CTLL-2 (T lymphocytes) | (72) | ||
| Mouse | BaF/3 (pro-B cells) | (72) | ||
| Dog | MDCK (kidney epithelial cells) | (67) | ||
| Rat | L6 (skeletal myoblasts) | (71) | ||
| Exosome maturation | Human | Jurkat (T cell leukemia) | (94) | |
| Migration | Human | H1299 (lung carcinoma) | (65) | |
| Matrix invasion | Human | MDA-MB-231 (breast cancer cells) | (66) | |
| Multivesicular body secretion | Human | Jurkat (T cell leukemia) | (95) | |
| Human | Raji B (B lymphocytes) | |||
| Total cell | Cell proliferation, signaling | Human | HuH7, PLC/PRF/5, HLE, and Hep3B (hepatocellular carcinoma) | (50) |
a
nr, not reported.