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Schematic of gene-based therapies. Pathway (A) shows the central dogma of molecular biology. The regulation of protein translation through RNAi is shown in Pathway (B). Endogenous miRNAs, exogenous miRNAs, or synthetic siRNAs can bind mRNA and induce its degradation. Pathway (C) shows the production of recombinant proteins. Reprinted from a previous study Rose and Uludag (2013) with permission.
