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Hydrogel-based RNAi delivery strategies include encapsulation within a nanoparticle or the use of an RNAi conjugate. Degradable sequences, varied polymer charges, and crosslinking mechanisms control the rate of RNAi molecule release. Upon release, nanoparticles or RNAi molecules are able to interact with cell membranes and enter the cell, leading to gene silencing. Reprinted from a previous study Wang and Burdick (2017) with permission.
