TABLE 2.
All-cause and infectious-cause hospitalizations comparing HIV-exposed uninfected to HIV-unexposed children: crude incidence rates and incidence rate ratios per age interval
| ALL-CAUSE 1 | INFECTIOUS ILLNESS 2 | |||||||
|---|---|---|---|---|---|---|---|---|
| All children N=869 | HEU children N=459 | HU children N=410 | IRR (95% CI) HEU vs HU children3 | All children N=869 | HEU children N=459 | HU children N=410 | IRR (95% CI) HEU vs HU children3 | |
| Overall, n | 869 | 459 | 410 | 0·91 (0·76–1·10) | 869 | 459 | 410 | 1·40 (0·97–2·02) |
| Admissions | 475 | 261 | 214 | 155 | 101 | 54 | ||
| Person-time (cy) | 932·6 | 533·2 | 399·4 | 932·6 | 533·2 | 399·4 | ||
| Incidence/100 cy (95% CI) | 50·9 (46·5–55·3) | 48·9 (43·3–55·3) | 53·6 (46·9–61·3) | 16·6 (14·2–19·4) | 18·9 (15·6–23·0) | 13·5 (10·3–17·7) | ||
| 0 to 7 days, n | 869 | 459 | 410 | 0·82 (0·67–0·99) | 869 | 459 | 410 | 1·16 (0·43–3·11) |
| Admissions | 286 | 136 | 150 | 16 | 9 | 7 | ||
| Person-time (cy) | 16·5 | 8·7 | 7·8 | 16·5 | 8·7 | 7·8 | ||
| Incidence/100cy (95% CI) | 1734·5 (1544·7–1947·6) | 1566·8 (1324·4–1853·6) | 1920·8 (1636·8–2254·2) | 97·0 (59·4–158·4) | 103·7 (53·9–199·3) | 89·6 (42·7–188·0) | ||
| >7 days to 3 months, n | 849 | 444 | 405 | 2·85 (1·56–5·20) | 849 | 444 | 405 | 3·50 (1·68–7·30) |
| Admissions | 57 | 43 | 14 | 43 | 34 | 9 | ||
| Person-time (cy) | 191·5 | 99·4 | 92·1 | 191·5 | 99·4 | 92·1 | ||
| Incidence/100 cy (95% CI) | 29·8 (23·0–38·6) | 43·4 (32·1–58·3) | 15·2 (9·0–25·7) | 22·4 (16·6–30·3) | 34·2 (24·4–47·9) | 9·8 (5·1–18·8) | ||
| >3 to 6 months, n | 808 | 415 | 393 | 1·34 (0·68–2·63) | 808 | 415 | 393 | 1·21 (0·63–2·32) |
| Admissions | 49 | 29 | 20 | 37 | 21 | 16 | ||
| Person-time (cy) | 198·3 | 103·1 | 95·2 | 198·3 | 103·1 | 95·2 | ||
| Incidence/100cy (95% CI) | 24·7 (18·7–32·7) | 28·1 (19·5–40·5) | 21·0 (13·6–32·6) | 18·7 (13·5–25·8) | 20·4 (13·3–31·2) | 16·8 (10·3–27·4) | ||
| > 6 to 9 months, n | 782 | 405 | 377 | 1·01 (0·45–2·26) | 782 | 405 | 377 | 1·16 (0·46–2·93) |
| Admissions | 23 | 12 | 11 | 18 | 10 | 8 | ||
| Person-time (cy) | 191·1 | 99·2 | 91·9 | 191·1 | 99·2 | 91·9 | ||
| Incidence/100cy (95% CI) | 12·0 (8·0–18·1) | 12·1 (6·9–21·3) | 12·0 (6·6–21·6) | 9·4 (5·9–15·0) | 10·1 (5·4–18·7) | 8·7 (4·3–17·4) | ||
| >9 to 12 months, n | 745 | 384 | 361 | 1·22 (0·56–2·65) | 745 | 384 | 361 | 1·15 (0·49–2·65) |
| Admissions | 25 | 14 | 11 | 22 | 12 | 10 | ||
| Person-time (cy) | 179·8 | 91·9 | 87·9 | 179·8 | 91·9 | 87·9 | ||
| Incidence/100 cy (95% CI) | 13·9 (9·4–20·6) | 15·2 (9·0–25·7) | 12·5 (6·9–22·6) | 12·2 (8·1–18·6) | 13·1 (7·4–23·0) | 11·4 (6·1–21·2) | ||
| > 12 months, n | 664 | 335 | 329 | 0·64 (0·27–1·49) | 664 | 335 | 329 | 0·71 (0·23–2·13) |
| Admissions | 35 | 28 | 8 | 19 | 15 | 4 | ||
| Person-time (cy) | 155·5 | 130·9 | 24·6 | 155·5 | 130·9 | 24·6 | ||
| Incidence/100cy (95% CI) | 22·5 (16·3–31·3) | 20·6 (14·1–30·1) | 32·5 (16·2–64·9) | 12·2 (7·8–19·1) | 11·5 (6·9–19·0) | 16·2 (6·1–43·3) | ||
Abbreviations: IRR, incidence rate ratio; CI, confidence interval; cy, child-years
1
Hospitalized for at least 2 days, all primary diagnoses
2
Hospitalization for at least 2 days, primary diagnosis infectious in origin
3
Overall IRR from crude Poisson regression analysis with variance corrected for clustering by child; IRR per age category from crude regression analysis restricted by age intervals without variance correction