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. 2020 May 12;11:674. doi: 10.3389/fphar.2020.00674

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Copyright © 2020 Rojas-Carvajal, Sequeira-Cordero and Brenes

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Behavioral kinetics in the open-field test. Locomotion (A) and rearing (B) over minutes (left panel), days (middle panel), and their cumulative averages (right panel). Data correspond to meters (A) and frequency (B) expressed as mean ± SEM. SH2: Standard housing with two rats. SH5, standard housing with five rats. CEE: Continuous environmental enrichment; REE, restricted and unpredictable environmental enrichment. Single, pairwise-comparisons between groups, CEE and REE vs. SH2 and SH5: *p < .05; ***p < .001; SH2 vs. SH5: ^# p < .05; ^### p < .001; and SH5 vs. CEE and REE: ⁺⁺ p < .01.