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. 2020 May 12;11:674. doi: 10.3389/fphar.2020.00674

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Copyright © 2020 Rojas-Carvajal, Sequeira-Cordero and Brenes

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of environmental enrichment on gene expression. Relative mRNA expression of BDNF (A), TrkB (B) and CREB (C) in the hippocampus, and BDNF (D) and DNMT3A (E) in the dorsal striatum. The mRNA expression levels in all the brain regions analyzed (F). Data correspond to percentages relative to the mean of the SH5 group (A–E) or 2^−dCT values (F) expressed as mean ± SEM. SH5, standard housing with five rats. CEE, continuous environmental enrichment; REE, restricted and unpredictable environmental enrichment. Symbols correspond to single, planned comparisons between groups. REE vs. CEE and SH5: ^ΘΘ p < .01. REE vs. CEE: ^@ p < .05. CEE and REE vs. SH5: **p < .01.