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Human induced pluripotent stem cell derived cardiomyocytes. (A) Generation of hiPSCs by cell reprogramming of somatic cells from patients or healthy donors or via CRISPR-Cas9 gene editing for the generation of isogenic pairs. (B) Current maturation strategies for hiPSC-CMs at cell level (2D strategies) or in multicellular model (3D strategies). (C) Possible methods for the assessment of electrophysiological and contractile properties.
