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. 2020 May 12;14:445. doi: 10.3389/fnins.2020.00445

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Copyright © 2020 Yang, Yuan, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CLTUS system design. In the modulation experiment, the specific phase of the theta rhythm is detected online. In the experiment on the inhibition of the seizure of TLE, the seizure is detected online by calculating the standard deviation of the amplitude and CL. Based on the detection results, the computer sends a TTL high-level signal, which triggers the function generator to send a signal. The signal is sent to the amplifier, which drives the ultrasound transducer to emit an ultrasound wave for CLTUS.