Table 2.
Results of the multivariable Cox regression analysis for the influence of CIT on 1-year graft survival in liver transplant recipients with different underlying diseases.
| Cold ischemia time (hours) | n | HR | 95 % CI | P |
|---|---|---|---|---|
| All underlying diseases | ||||
| ≤ 5 | 5,583 | 1 (ref) | – | – |
| 6–7 | 10,800 | 1.04 | 0.95–1.13 | 0.40 |
| 8–9 | 11,106 | 1.14 | 1.05–1.25 | 0.003 |
| 10–11 | 7,448 | 1.22 | 1.11–1.34 | <0.001 |
| 12–13 | 3,629 | 1.43 | 1.29–1.59 | <0.001 |
| ≥14 | 1,722 | 1.67 | 1.47–1.89 | <0.001 |
| HCC | ||||
| ≤ 5 | 1,576 | 1 (ref) | – | – |
| 6–7 | 3,319 | 0.92 | 0.78–1.09 | 0.36 |
| 8–9 | 3,086 | 1.06 | 0.90–1.26 | 0.47 |
| 10–11 | 1,851 | 1.33 | 1.11–1.58 | 0.002 |
| 12–13 | 798 | 1.41 | 1.15–1.74 | 0.001 |
| ≥14 | 323 | 1.80 | 1.39–2.33 | <0.001 |
| HCV-induced liver cirrhosis | ||||
| ≤ 5 | 1,341 | 1 (ref) | – | – |
| 6–7 | 2,481 | 1.03 | 0.87–1.22 | 0.73 |
| 8–9 | 2,617 | 1.24 | 1.05–1.47 | 0.011 |
| 10–11 | 1,772 | 1.31 | 1.10–1.57 | 0.002 |
| 12–13 | 873 | 1.51 | 1.23–1.85 | <0.001 |
| ≥14 | 485 | 1.64 | 1.30–2.09 | <0.001 |
| Alcoholic cirrhosis | ||||
| ≤ 5 | 1,038 | 1 (ref) | – | – |
| 6–7 | 1,985 | 1.14 | 0.93–1.40 | 0.21 |
| 8–9 | 2,198 | 1.07 | 0.87–1.32 | 0.50 |
| 10–11 | 1,497 | 1.09 | 0.88–1.36 | 0.42 |
| 12–13 | 779 | 1.45 | 1.13–1.84 | 0.003 |
| ≥14 | 381 | 1.73 | 1.31–2.28 | <0.001 |
| Other | ||||
| ≤ 5 | 1,628 | 1 (ref) | – | – |
| 6–7 | 3,015 | 1.12 | 0.94–1.32 | 0.20 |
| 8–9 | 3,205 | 1.18 | 1.00–1.39 | 0.055 |
| 10–11 | 2,328 | 1.15 | 0.96–1.37 | 0.12 |
| 12–13 | 1,179 | 1.36 | 1.11–1.65 | 0.003 |
| ≥14 | 533 | 1.59 | 1.25–2.01 | <0.001 |
Hazard ratios (HR) with 95% confidence interval (CI) of categorized CIT are shown. HCC, hepatocellular carcinoma; HCV, hepatitis C virus; ref, reference.