TABLE 2.

Summary of advantages and disadvantages of the proposed strategies.

Strategy	Advantages	Disadvantages
Synthetic biomaterial (PL), (PG), (PCL), (PGLA)	Degrading rate control Homogeneous production Reducing variability in immune response	Limited ability to induce endogenous repair responses
Synthetic biomaterial combined with natural compounds	Resistance to protein degradation Optimizing repair features	Hydrophobicity superficial
Collagen biomaterial	Contributing to growth, differentiation, and cell migration	Immunogeneity Low mechanical resistance
Alginate biomaterial	Biodegradable Hypoallergenic	Combined with synthetic compounds for greater consistency
Hyaluronic acid biomaterial	Anti-inflammatory properties Support for cell survival biocompatibility Non-stick properties	Easily degradable Possible formation of fibrosis
Biomaterial combined with exogenous cells	Less infiltration of reactive cells into the biomaterial Increase in neural precursors, modulates neuroinflammation, promotes neuroprotection	Possible neoplastic formation Cells do not integrate into the tissue
Biomaterial combined with bioactive molecules	Promoting neuroreparation processes Improves invasion and colonization of host tissue	Its use is restricted to 2–3 weeks