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. 2020 May 12;11:881. doi: 10.3389/fimmu.2020.00881

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Copyright © 2020 Hashem, Kammala, Thaxton, Griffin, Mullany, Panettieri, Subramanian and Das.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduced cellular infiltration and chemokine expression in Cd2^−/− mice challenged with HDME. (A,B) BALF from WT and Cd2^−/− mice injected with PBS or challenged with HMDE were analyzed for total leukocyte counts (TLC, A) and diffential cell counts (showing total monocytes, eosinophils, monocytes, neutrophils, and lymphocytes, B). Data is shown as mean ± SEM and pooled from 4 independent experiments with a total of 10–16 mice per cohort. (C,D) Lung tissue homogenates of WT and Cd2^−/− mice injected with PBS or HMDE were analyzed for mRNA levels of Ccr8 (C) and various neutrophil (D) and eosinophil chemokines (E) by qPCR. Data is shown as mean fold change ± SEM and pooled from 3 independent experiments with a total of 8–13 mice per cohort. Statistical significance was determined by Student's unpaired t-test with Welch's correction. *p ≤ 0.05, **p ≤ 0.01.