Table 2.
Host shutoff-associated proteins inhibit various proinflammatory cytokines and cytokines
| Protein | Pathogen | Target protein | Mechanism |
|---|---|---|---|
| VHS | HSV-1 | IL-1β, IL-8 | mRNA degradation |
| MIP-1α | |||
| NF-KB | |||
| MHC-I/II | |||
| RNase L | |||
| JAK1 | |||
| STAT2 | |||
| SOCS3 | |||
| VHS | BHV-1 | MHC-I/II | mRNA degradation |
| BGLF5 | EBV | HLAI/II | mRNA degradation |
| CD1d | |||
| ICP27 | HSV-1 | NF-KB | Inhibition of NF-kB transcriptional activity by repressing Daxx sumoylation |
| ICP27 | HSV-1 | p65 | Inhibition of p65 acetylation |
| ICP27 | HSV-1 | STAT1 | Inhibition of STAT-1 phosphorylation and nuclear accumulation |
| ICP27 | BHV-1 | IFNβ | Inhibition of IFN-β1/3 promoter activity |