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. 2020 May 12;14:97. doi: 10.3389/fncel.2020.00097

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Copyright © 2020 Du, Wang, Han and Feng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The inflammatory response in the brain was increased in type 2 diabetes mellitus (T2DM) mice exposed to intermittent hypoxia (IH). (A) Tumor necrosis factor-α (TNF-α) and interleukin-1 β (IL-1β) in mouse serum were measured by enzyme-linked immunosorbent assay (ELISA). (B) NLRP3 expression was determined by immunohistochemistry (IHC). Scale bars in the right lower corner represent 20 mm. (C) NLRP3, caspase 1, TNF-α and IL-1β levels were determined by Real-time quantitative polymerase chain reaction (qRT-PCR). (D,E) NLRP3, caspase 1, TNF-α and IL-1β levels were determined by western blot. The data are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 vs. the C57 group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. the KK+IH group.