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IH upregulated MALAT1 and downregulated miRNAs in the brains of T2DM mice. (A,C) MALAT1 and the miRNAs miR-224-5p, miR-216b-5p and miR-485-5p were analyzed by qRT-PCR. (B) Base-pairing sites for MALAT1 and miR-224-5p, miR-216b-5p and miR-485-5p. (D) Base-pairing sites for miR-224-5p, miR-216b-5p and miR-485-5p with NLRP3. All results are presented as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 vs. the C57 group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. the KK+IH group.
