REAGENT or RESOURCE	SOURCE	IDENTIFIER
Biological Samples
Patients swabs and blood samples	Guangzhou Eighth People’s Hospital	N.A.
Critical Commercial Assays
Laboratory assessments of biochemistry were measured with the platform of Roche. ALT/AST was detected by rate assay, TBIL was detected by oxidase method.	Roche	Lab staff of Guangzhou Eighth People’s Hospital
Nucleic Acid Isolation Kit (Da’an Gene Corporation, Cat: DA0630) Automatic workstation Smart 32 (Da’an Gene Corporation) RT–PCR reagent (Da’an Gene cooperation, Cat DA0930)	Da’an Gene Corporation, Sun Yat-sen University, Guangzhou, China	Lab staff of Guangzhou Eighth People’s Hospital
Oligonucleotides
PCR primer and probe set target toORF1ab (FAM reporter) and N (VIC reporter) genes separately. 1. Primer sequences for the ORF1ab genes: Forward primer (F): CCCTGTGGGTT TTACACTTAA. Reverse primer (R): ACGATTGTGCA TCAGCTGA. Fluorescent probe (P): 5′-FAM-CCGTCTGCGGTATGTGGAAAGGT TATGG-BHQ1-3′ 2. Primer sequences for the N genes: Forward primer (F): GGGGAACTT CTCCTGCTAGAAT. Reverse primer (R): CAGACATTTTG CTCTCAAGCTG. Fluorescent probe (P): 5′-FAM-TTGCTGCTGCTTGACAGATT-TAMRA-3′ Nucleic acid extraction and real-time fluorescence RT-PCR reaction system and reaction conditions refer to the relevant manufacturer kit instructions	Da’an Gene Corporation, Sun Yat-sen University, Guangzhou, China	Lab staff of Guangzhou Eighth People’s Hospital
Software and Algorithms
SPSS (Statistical Package for SPSS, version 26.0)	IBM, Armonk, NY