Table 2.
Univariate linear regression associations with bone mineral density among HIV-seropositive and seronegative WIHS participants.
| Variable | Weight bearing bones |
Non-weight bearing bones |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Lumbar spine |
Total hip |
Femoral neck |
Distal radius |
Ultradistal radius |
||||||
| Coefficient (95% CI) |
p-Value | Coefficient (95% CI) |
p-Value | Coefficient (95% CI) |
p-Value | Coefficient (95% CI) |
p-Value | Coefficient (95% CI) |
p-Value | |
| Sclerostin | 0.47 (0.29, 0.64) |
<0.001 | 0.31 (0.17, 0.44) |
<0.001 | 0.34 (0.19, 0.49) |
<0.001 | 0.21 (0.10, 0.33) |
<0.001 | 0.14 (0.08, 0.22) |
<0.001 |
| HIV Status | −0.09 (−0.15,−0.03) |
0.002 | −0.07 (−0.11,−0.02) |
0.003 | −0.06 (−0.11,−0.02) |
0.010 | −0.03 (−0.06, 0.01) |
0.21 | −0.04 (−0.06,−0.02) |
0.002 |
| Age (per 5-year) |
−0.04 (−0.06,−0.01) |
0.010 | −0.02 (−0.04, 0.01) |
0.064 | −0.01 (−0.03, 0.01) |
0.40 | −0.01 (−0.02, 0.02) |
0.77 | −0.01 (−0.02, 0.01) |
0.11 |
| BMI (per 5-unit) |
0.04 (0.01, 0.06) |
0.003 | 0.05 (0.03, 0.07) |
<0.001 | 0.04 (0.02, 0.06) |
<0.001 | 0.03 (0.02, 0.05) |
<0.001 | 0.03 (0.02, 0.04) |
<0.001 |
| Race: white vs black |
−0.06 (−0.14, 0.02) |
0.13 | −0.05 (−0.11, 0.01) |
0.10 | −0.09 (−0.15,−0.02) |
0.013 | −0.07 (−0.12,−0.02) |
0.010 | −0.04 (−0.07,−0.01) |
0.026 |
| Race: other vs black |
−0.11 (−0.19,−0.03) |
0.006 | −0.05 (−0.11, 0.02) |
0.16 | −0.05 (−0.12, 0.02) |
0.13 | −0.04 (−0.09, 0.01) |
0.14 | −0.01 (−0.04, 0.03) |
0.78 |
| Menopause | −0.11 (−0.17,−0.06) |
<0.001 | −0.07 (−0.11,−0.02) |
0.004 | −0.04 (−0.09, 0.01) |
0.10 | −0.02 (−0.07, 0.01) |
0.15 | −0.03 (−0.05,−0.01) |
0.032 |
| IL-6 | −0.10 (−0.96, 0.77) |
0.83 | 0.12 (−0.54, 0.77) |
0.73 | 0.26 (−0.47, 0.99) |
0.48 | 0.23 (−0.32, 0.79) |
0.41 | 0.24 (−0.11, 0.60) |
0.18 |
| TNFα | −0.01 (−0.04, 0.03) |
0.65 | 0.01 (−0.02, 0.03) |
0.80 | −0.01 (−0.04, 0.02) |
0.63 | −0.01 (−0.03, 0.02) |
0.85 | −0.01 (−0.03, 0.01) |
0.23 |
| PINP | −0.18 (−0.27,−0.08) |
<0.001 | −0.13 (−0.21,−0.06) |
<0.001 | −0.11 (−0.19,−0.03) |
0.005 | −0.07 (−0.13,−0.01) |
0.021 | −0.07 (−0.11,−0.04) |
<0.001 |
| CTX | −0.28 (−0.42,−0.14) |
<0.001 | −0.23 (−0.33,−0.12) |
<0.001 | −0.22 (−0.34,−0.10) |
<0.001 | −0.17 (−0.26,−0.08) |
<0.001 | −0.17 (−0.22,−0.11) |
<0.001 |