Table 1.
Argonaute proteins, their guides and functions.
| Argonaute proteins | Types | Host | Guide | Classify | Function | Reference |
|---|---|---|---|---|---|---|
| Ago1-4 | Ago-like family | Homo sapiens | miRNA-guided RNA | eAgos | Interference and/or cleavage target gene | [16], [41] |
| PIWI1-4 | PIWI-like family | Homo sapiens | piRNA-guided RNA | eAgos | Transposon silencing and infertility | [57], [109] |
| Ago1-10 | Ago-like family | Arabidopsis thaliana | miRNA/siRNA-guided RNA | eAgos | Interference and/or cleavage target gene | [110] |
| Ago1-27 | Ago-like family | Caenorhabditis elegans | mRNA/piRNA-guided RNA | eAgos | Interference, cleavage and silencing | [17] |
| TtAgo | Long Ago | Thermus thermophilus | siDNA-guided DNA/RNA | pAgos | Host defence, cleavage, gene-editing | [92] |
| PfAgo | Long Ago | Pyrococcus furiosus | siDNA-guided DNA | pAgos | Host defence, cleavage, interference | [72] |
| MjAgo | Long Ago | Methanocaldococcus jannaschii | siDNA-guided DNA | pAgos | Silencing, cleavage and gene-editing | [15] |
| NgAgo | Long Ago | Natronobacterium gregoryi | siDNA-guided DNA | pAgos | Silencing, interference | [87] |
| MpAgo | Long Ago | Marinitoga piezophila | siRNA-guided RNA/DNA | pAgos | Cleavage ssDNA | [111] |
| TpAgo | Long Ago | Thermotoga profunda | siRNA/miRNA-guided DNA | pAgos | Cleavage ssDNA | [111] |
| AfAgo | Long Ago | Archaeoglobus fulgidus | siRNA-guided mRNA | pAgos | Cleavage mRNA | [112] |
| AaAgo | Long Ago | Aquifex aeolicus | siDNA-guided RNA | pAgos | Cleavage, interference | [113] |
| RsAgo | Long Ago | Rhodobacter sphaeroides | siRNA-guided DNA | pAgos | Host defence and target cleavage | [5] |
Note: miRNA: microRNA; eAgos: eukaryotic Argonaute proteins; siRNA: small interfering RNA; piRNA: P-element-induced wimpy testis (PIWI)-interacting RNA; pAgos: prokaryotic Argonaute proteins; ssDNA: single-stranded DNA.