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. 2020 Apr 23;23:21–28. doi: 10.1016/j.jot.2020.03.007

Figure 1.

Figure 1

UCMSCs could preserve cartilage structure and attenuate OA progression induced by MIA injection. (A) Safranin O/Fast green staining of normal joints, vehicle, single injection of UCMSCs (UCMSCs ​× ​1), three-time UCMSCs injection (UCMSCs ​× ​3) and three-time CHO injection into MIA-induced rat knee OA. (Scale bars, 200 ​μm.) (B) and (C) Mankin ​and OARSI scores confirmed that both UCMSCs and CHO could significantly alleviate cartilage erosion triggered by MIA. Furthermore, repeated UCMSCs exhibited better effects compared with single dosing and three-time CHO injection. ∗∗p ＜ 0.01, ∗∗∗p ＜ 0.001 ​ and ∗∗∗∗p ＜ 0.0001. (D) Average thicknesses of articular cartilage in tibial plateau. ∗p ＜ 0.05, ∗∗p ＜ 0.01 and ∗∗∗∗p ＜ 0.0001. (E) Percentages of uncalcified zone over the whole cartilage layer. ∗∗p ＜ 0.01. Results are representative of at least three independent experiments and expressed as mean ​± ​standard deviation. CHO ​ = chondrocytes; MIA = monosodium iodoacetate; OA = osteoarthritis; UCMSCs ​ = umbilical cord–derived mesenchymal stem cells; UCZ% = uncalcified cartilage zone thickness percentage, uncalcified cartilage thickness/total cartilage thickness ​× ​100%.