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. 2020 May 1;23(5):101129. doi: 10.1016/j.isci.2020.101129

Figure 5.

Figure 5

Evaluating Predictive Capability of KiDNN

(A) A plot showing relative migration of Hs578t cells in response to DMSO control, SU11652 (1 μM), or Dovitinib (1 μM). Each point is a mean of three replicates, and the error bars denote SEM.

(B) Representative images of Hs578t cells at time 0 h (wounding) and 48 h post wounding. Wound area is highlighted in yellow, and the migrating cells in the wound area are shown in blue mask.

(C) A plot showing comparison of KiDNN-predicted and measured percent migration in response to 32 inhibitors in FOCUS cells using LOOCV. Migration in response to untreated/DMSO control was 70%.

(D) A plot showing KiDNN-predicted response to 178 small molecule kinase inhibitors (146 untested) in FOCUS cells. The black circles denote the predicted percent migration, whereas the blue circles and red circles denote the percent migration for 32 experimentally validated kinase inhibitors and 7 unseen inhibitors respectively. The kinase inhibitors are ranked by predicted migration.