Figure 6.

Long-term adipocyte-specific Beclin1 KO impairs autophagy and mitochondrial integrity in BAT. (A) Schematic diagram illustrating the experimental schedule for tamoxifen (5 days) and CL316243 treatment. (B) Immunoblot analysis of BAT of Beclin1^adipoq KO mice and WT controls (n = 8 per condition, mean ± SEM; two-way ANOVA; the significance of Beclin1 KO effects is indicated). (C) Representative electron micrographs of BAT of Beclin1^adipoq KO mice and WT controls. Magnified views of boxed regions are presented. The arrows indicated the accumulation of autophagosomes.