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. 2020 May 18;16:1744806920924511. doi: 10.1177/1744806920924511

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Effect of BWSTT on CREB and p-CREB synthesis in the distal spinal cord of SCI rats with or without blocking TrkB signaling. (a) Western blot image of CREB and p-CREB in the Sham group, the SCI/PBS group, the SCI-TT/PBS group, the SCI/TrkB-IgG group, and the SCI-TT/TrkB-IgG group at the end of the experiment. (b) The statistical graph of the relative density of CREB. (c) The statistical graph of the relative density of p-CREB. n = 4 rats per group. *P < 0.05, **P < 0.01. Statistical analysis was performed using one-way ANOVA followed by the LSD or Bonferroni test.

BWSTT: body weight-supported treadmill training; TT: treadmill training; SCI: spinal cord injury; PBS: phosphate-buffered saline; TrkB: tropomyosin-related kinase B; CREB: cAMP-response element binding protein; p-CREB: Phospho-CREB; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; ANOVA: analysis of variance.