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. 2020 Apr 11;8(4):86. doi: 10.3390/biomedicines8040086

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Tussilagone treatment suppressed the AOM/DSS-induced colon carcinogenesis. (a) The chemical structure of tussilagone. (b) The experimental protocol for the development of a colitis-associated colon carcinogenesis model. (c) The weekly recording of the body weights during the experiment and (d) the representative macroscopic features of the colons of the mice in each group. (e) The number of tumors observed in the colons of mice treated with AOM/DSS and tussilagone. The sizes of tumors were measured and classified as < 3 mm and > 3 mm. (f) Total tumor area, (g) colon weight, (h) colon length and (i) the ratio of the colon weight and length per mouse. Results are expressed as the means ± SEM (n = 9 per group). * P < 0.05, ** P < 0.01, *** P < 0.001, compared with AOM/DSS-treated mice. (j) Histopathology of the colonic mucosa by H&E staining (upper, ×40 magnification; lower, ×100 magnification; bar = 100 µm).

Tussilagone treatment suppressed the AOM/DSS-induced colon carcinogenesis. (a) The chemical structure of tussilagone. (b) The experimental protocol for the development of a colitis-associated colon carcinogenesis model. (c) The weekly recording of the body weights during the experiment and (d) the representative macroscopic features of the colons of the mice in each group. (e) The number of tumors observed in the colons of mice treated with AOM/DSS and tussilagone. The sizes of tumors were measured and classified as < 3 mm and > 3 mm. (f) Total tumor area, (g) colon weight, (h) colon length and (i) the ratio of the colon weight and length per mouse. Results are expressed as the means ± SEM (n = 9 per group). * P < 0.05, ** P < 0.01, *** P < 0.001, compared with AOM/DSS-treated mice. (j) Histopathology of the colonic mucosa by H&E staining (upper, ×40 magnification; lower, ×100 magnification; bar = 100 µm).