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. 2020 Mar 31;9(4):67. doi: 10.3390/biology9040067

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Secretion of interleukin-1 (IL1) receptor antagonist (IL1RN) by TILs. (A) Analyses of cytokines/chemokines profiles by comparing conditioned media prepared from TRAMP-C1, PBMC from normal C57BL/6 mice (PBMC#1, PBMC#2), and three different TILs (TILs #1-#3). Reduction of secreted proteins in the conditioned media are labeled with arrows. Induction of IL1 receptor antagonist (IL1RN) is enclosed with a dashed box. (B) Elevated expression of Il1rn mRNA in tumor tissues (tumor #1-#3). (C) Comparison of Il1rn mRNA expressions between tumor tissues (tumor#1-#3) and their derived TILs (TILs #1-#3). The samples are the same as described in Figure 3 and Il1rn levels are elevated in TILs. qPCR measurements were derived from three replicates and results are presented as the mean ± SD. Student’s t-test. * p < 0.05, *** p < 0.001, **** p < 0.0001.