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. 2020 Apr 11;9(4):172. doi: 10.3390/antibiotics9040172

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of fosfomycin disodium salt (FDS) on microphthalmia-associated transcription factor (MITF), tyrosinase related protein 1 (TRP-1), tyrosinase related protein 2 (TRP-2), and tyrosinase expression in B16F10 cells. Cells were treated with various concentrations of FDS (0.125, 0.25, and 0.5 mg/mL). Protein levels were examined by Western blotting. (a) Result of Western blotting, and protein levels of (b) MITF, (c) TRP-1, (d) TRP-2, and (e) tyrosinase. Results are expressed as a percentage of the control. The data are presented as mean ± SD of at least three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. untreated cell. SD: standard deviation. TRP: tyrosinase-related protein. MITF: microphthalmia-associated transcription factor.