Scheme 5.
Reagents and solvents: (a) TEA, MsCl, DCM, 3 h; (b) 2,6-Difluoro-3-hydroxybenzamide, K₂CO₃, DMF, 80 °C, 16 h; (c) m-CPBA, DCM, RT, 18 h; (d) catechol, NaH, DMF, 100 °C, 72 h; (e) Triphenylphosphine, DEAD, THF, 60 °C, 24 h.
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