Table 1.
Measured minimum inhibitory concentration (MIC) values for melittin, polymyxin and imipenem.
| Strain/Resistance Profile | Melittin (µg/mL) | Polymyxin c (µg/mL) | Imipenem d (µg/mL) |
|---|---|---|---|
| A. baumannii ATCC 19606 | 17 | 0.25 | 0.25 |
| A. baumannii 31852 (S) | 20 | 0.25 | ≤0.125 |
| A. baumannii 33677 (XDR) | 31 | 0.25 | 16 |
| A. baumannii 96734 (XDR) | 45.5 | 0.25 | 16 |
| A. baumannii 100 (PDR b) | >284 | 8 | 32 |
The MIC values were determined using a standard microdilution assay with triplicate samples for each peptide concentration. Identical results were obtained from two separate experiments; therefore, no errors are reported. b For this strain, melittin did not achieve full killing at the maximum concentration of 85 µg/mL, and in this case, other concentrations with no effect were tested (142 and 284 µg/mL); c MIC values for polymyxin: S ≤ 2 µg/mL, R ≥ 4 µg/mL; d MIC values for imipenem: S ≤ 2 µg/mL, I = 4 µg/mL, R ≥ 8 µg/mL.