Table 1.
Phenotype—Genotype Interactions tested.
| Gene | Variants Tested | Relevant Phenotype |
|---|---|---|
| ADRB1 | rs1801252, rs1801253 | Beta-Blocker Efficacy |
| APOL1 | rs73885319, rs60910145, rs71785313 | Risk of CKD |
| CYP2C19 | rs4244285, rs4986893, rs28399504, rs72552267, rs41291556, rs6413438, rs12248560 | Clopidogrel Efficacy |
| CYP2C9 | rs1799853, rs1057910, rs28371686, rs9332131, rs7900194, rs28371685 | Losartan Efficacy |
| CYP2D6 | rs16947, rs1135840, rs35742686, rs3892097, rs1065852, rs5030655, rs5030867, rs5030865(A), rs5030656, rs1065852, rs1135840, rs5030865(T), rs28371706, rs61736512, rs59421388, rs1135840, rs28371725 | Metoprolol Efficacy |
| CYP3A4 | rs55785340, rs35599367 | Tacrolimus Dosing |
| CYP3A5 | rs776746, rs10264272, rs41303343 | Tacrolimus Dosing |
| F7 | rs6046 | Amlodipine Efficacy |
| FGF5/SH2B3/EBF1 | rs1458038, rs3184504, rs4551053 | Thiazide Efficacy |
| GRK4 | rs2960306, rs1024323 | Beta-Blocker Efficacy |
| LINC00923 | rs653747 | Risk of CKD |
| LOC105369332 | rs2282538 | Risk of CKD |
| NAT2 | rs1801279, rs1801280, rs1799930, rs1799931 | Hydralazine Efficacy |
| NEDD4L | rs4149601 | Diuretic Efficacy |
| NPHS1 | rs3814995 | Angiotensin receptor blocker efficacy |
| SLC3A2 | rs489381 | Risk of CKD |
| SLCO1B1 | rs4149056, rs4149015 | Simvastatin Dosing |
| SHROOM3 | rs17319721, rs4371638, rs13146355 | Risk of CKD |
| TPMT | rs1800462, rs1800460 and rs1142345, rs1800460, rs1142345, rs1800584 | Azathioprine Dosing |
| UMOD/PDILT | rs4293393, rs12917707, rs11864909 | Risk of CKD |
| VASP | rs10995 | Thiazide Efficacy |
| VKORC1 | rs9923231 | Warfarin Sensitivity |
| YEATS4 | rs7297610 | Thiazide Efficacy |
CKD: Chronic kidney disease.