Table 5.

Comparison of the custom-designed multi-gene panel mutational results with literature reference data.

Sample Type	Gene	Frequency in Our Series	Frequency Reported in the Literature	References
Brain neoplasms	IDH1	22.1	30–39	[1,32]
	IDH2	1.9	1–2.8	[1,32]
NSCLCs	EGFR	14.1	13.9–22.2	[4,12]
	KRAS	38.9	29.7–40	[4,12,34]
CRCs	KRAS	44.6	34–44.2	[1,4]
	NRAS	5.4	4–4.5	[1,4]
	BRAF	15.1	10–11.2	[1,4]
Thyroid nodules	BRAF	19.2	13.7–22 *	[1,37,38]
	HRAS	2.5	4	[1,39]
	KRAS	3.3	2	[1,39]
	NRAS	8.5	8	[1,39]
	PIK3CA	8.4	4	[1]
	TP53	7.5	11	[1]
	TERT	9.8	11	[1]
Melanomas	BRAF	41.3	36–44	[1,4]
	NRAS	21.4	17–23.4	[1,4]
	c-Kit	1.8	6.6–8	[1,4]
Pancreatic lesions	KRAS	46.2	~45–55	[1,35]

* Values refer to references that have a distribution of preoperative cytology samples comparable with that of our series. NSCLCs: non-small cell lung carcinomas; CRCs: colorectal carcinomas.