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. 2020 Mar 19;11(5):615–623. doi: 10.1021/acsmedchemlett.9b00664

Figure 4.

Figure 4

Real-time PCR analysis of STAT-dependent genes in macrophages. RAW264.7 cells were stimulated with IFNγ+IL-6 for 1 h in the absence or presence of 12.5 μM of SOCS3 peptidomimetics and NC peptide. The mRNA expression levels of Cxcl10 (A), Ccl5 (B), and Nox2 (C) were normalized to 18S and expressed as fold increases over basal condition (arbitrary set as 1). Mean ± SEM of three independent experiments (#P < 0.05, ##P < 0.01, ###P < 0.001 vs basal; *P < 0.05, **P < 0.01, ***P < 0.001 vs cytokines).