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. 2020 Apr 7;11(5):713–719. doi: 10.1021/acsmedchemlett.9b00561

Scheme 4. Synthesis of Dual Inhibitors 15ad Isolated as TFA Salts.

Scheme 4

Reagents and conditions: (a) DMF, K2CO3; 135 °C, 55 min, MW irradiation; (b) for 14ac: H2, Pd/C 10%, MeOH, 4 bar, RT, 12 h; for 14d: H2 atmosphere and MeOH:THF 1:1 as solvent, 12 h; (c) LiOH, RT, 96 h.