Table 2. IC50 Values of Compounds 15a–d, SAHA, and CX-4945 against Four Human Tumor Cell Lines.
IC50 values (μM) |
||||
---|---|---|---|---|
Cpd | LNCaP | PC3 | MCF-7 | A549 |
15a | >100 | >100 | >100 | >100 |
15b | >100 | >100 | >100 | >100 |
15c | 16.31 ± 0.7 | 40.42 ± 4.4 | 52.48 ± 10.0 | 104.73 ± 7.9 |
15d | 66.70 ± 5.0 | >100 | >100 | >100 |
SAHA | 0.69 ± 0.1 | 2.03 ± 0.1 | 1.26 ± 0.1 | 3.14 ± 0.2 |
CX-4945 | 6.52 ± 0.6 | 10.87 ± 0.6 | 9.41 ± 0.3 | 11.60 ± 1.8 |