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. 2020 Mar 5;11(5):664–670. doi: 10.1021/acsmedchemlett.9b00538

Scheme 1. Preparation of SI306-Linker/Hydrolyzable Function.

Scheme 1

Reagents and Conditions: (i) 1-(2-hydroxyethyl)piperazine, HOBt, EDC·HCl, CH2Cl2, rt, 12 h. (ii) NaHCO3, triphosgene, CH2Cl2 dry, from 0 °C to rt, 6 h. (iii) Linker 2, CH2Cl2 dry, rt, 72 h.