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. 2019 Dec 10;11(5):638–644. doi: 10.1021/acsmedchemlett.9b00515

Figure 3.

Figure 3

(a) Percent inhibition of intramacrophage MTB (Cell line J774A.1, murine origin) in the presence of 5d, moxifloxacin (MOX), or isoniazid (INH). Concentrations: 5d (1 x MIC = 0.32 μg/mL; 5 x MIC = 1.6 μg/mL, and 10 x MIC = 3.2 μg/mL); INH (1 x MIC = 0.06 μg/mL; 5 x MIC = 0.30 μg/mL, and 10 x MIC = 0.60 μg/mL); MOX (1 x MIC = 0.07 μg/mL; 5 x MIC = 0.35 μg/mL, and 10 x MIC = 0.70 μg/mL). The results are the mean and standard error of experiments performed in duplicate. * = Statistically different from the untreated control (P < 0.05) by GraphPad Prism (One-way ANOVA with Dunnett’s Multiple Comparison Post Test). (b) Intracellular activity of 5d via HT-SPOTi assay.