Table 3. Biological Evaluation of Compounds against Bacterial and Intracellular Strains.

	M. tuberculosis MIC (μg/mL)
		CCM	CCM
Cmpd	H37Rva	11.1a	10.1a	GIC50	SIb
5a	0.5–0.25	1	0.0025	23.4	47–94
5d	0.06a-0.3c	0.12	<0.000625	11.7	195–39
5i	0.25–0.12	0.5	0.00125	5.8	23–48
5l	0.25–0.12	0.5	<0.000625	3.9	16–32
INH	0.24
Rif	>0.06

^aM. tuberculosis clinical strains from Royal Free Hospital NHS Trust, London.

^bThe selectivity index is calculated as the ratio of the GIC₅₀ and the MIC observed against M. tuberculosis H37Rv.

^cMIC obtained from clinical strains from the Tuberculosis Research Laboratory, Sao Paulo.²²