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Effect of compounds 11 and 12 on relaxation of supercoiled pBR322 DNA by human recombinant topoisomerase II. Supercoiled DNA (DNA) was incubated with the enzyme in the absence (topo II) and in the presence of 11 and 12 at 100 μM (A) or 25 μM and 50 μM (B). Twenty μM m-AMSA was used as reference.
