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. 2020 Jan 24;11(5):691–697. doi: 10.1021/acsmedchemlett.9b00557

Figure 4.

Figure 4

Effect of compounds 3033 on the relaxation of supercoiled pBR322 DNA by human recombinant topoisomerase II. Supercoiled DNA (DNA) was incubated with topo II in the absence (topo II) and in the presence of 3033 at 100 μM (A), or at 25 μM and 50 μM (B).