Subject-specific volume estimates, volumeManual (Manual), volumeTAPAS (TAPAS), volumeGroup (Group), and volumePartial (Partial), were compared with clinical covariates available from the data collected at the Johns Hopkins Hospital (JHH) and the Brigham and Women's Hospital (BWH) and are represented in this table. Spearman's correlation coefficient (ρˆ) was obtained in the testing set for each iteration and averaged across folds. Clinical variables included Expanded Disability Status Scale (EDSS) score, disease duration in years, and timed 25-ft walk (T25FW) in seconds.