FIGURE 2.

Immunization with Aβ42, but not AOE1, enhanced Aβ pathology in the EAE/AD mice. (a) 6E10 immunostaining for plaques in the brains of EAE/AD mice immunized with Aβ42 or AOE1. Scale bars: red, 500 μm; black, 100 μm. (b, c) Quantification of plaque number (b) and area (c) in the brain sections of EAE/AD mice immunized with Aβ42 or AOE1. (d–g) The levels of soluble Aβ42 (d), insoluble Aβ42 (e), soluble Aβ40 (f), and insoluble Aβ40 (g) in the brain lysates of EAE/AD mice immunized with Aβ42 or AOE1 were detected by ELISA. Data shown are means ± SEM, from n = 8 mice per group. *P < .05, significantly different as indicated