FIGURE 2.

Comparison of the downstream events of the NR1I3 (CAR) and NR1I2 (PXR) signalling pathways in liver and brain. Most of the research aiming to characterise the signalling pathways of NR1I3 and NR1I2 has been conducted in liver, whilst organs such as the brain are much less studied. This issue is particularly important as brain endothelial cells and neurons express both receptors and the response to the ligand‐based activation of NR1I3 and NR1I2 appears vary amongst areas of the brain. This outcome is consistent with the tissue‐dependent effects of