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Integrin pharmacology and targeted integrin subunit(s)
| mAb | Isotype | Target |
|---|---|---|
| Efalizumab (Raptiva®) | hIgG1 | αL |
| R7.1 | mIgG1 | αL |
| TS1/22 | mIgG1 | αL |
| Natalizumab (Tysabri®) | hIgG4 | α4 |
| Vedolizumab (Entyvio®) | hIgG1 | α4β7 |
| Compound | Class | Target |
|---|---|---|
| LFA878 | Statin derivative | αL |
| BIRT377 | Hydantoin derivative | αL |
| XVA143 | Peptidomimetic | αLβ2 |
| Lifitegrast (Xiidra®) | Peptidomimetic | αLβ2 |
| Firategrast | Peptidomimetic | α4β1/α4β7 |
| RO0505376 | Peptidomimetic | α4β1/α4β7 |
Abbreviations: h, human; m, mouse.
